Cells digest portions of their interiors in a process known as autophagy to recycle nutrients, remodel and dispose of unwanted cytoplasmic constituents. This ancient pathway, conserved from yeast to humans, is now emerging as a central player in the immunological control of bacterial, parasitic and viral infections. The process of autophagy may degrade intracellular pathogens, deliver endogenous antigens to MHC-class-II-loading compartments, direct viral nucleic acids to Toll-like receptors and regulate T-cell homeostasis. This Review describes the mechanisms of autophagy and highlights recent advances relevant to the role of autophagy in innate and adaptive immunity. © 2007 Nature Publishing Group.
CITATION STYLE
Levine, B., & Deretic, V. (2007, October). Unveiling the roles of autophagy in innate and adaptive immunity. Nature Reviews Immunology. https://doi.org/10.1038/nri2161
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