An update on medication management of behavioral disorders in autism topical collection on child and adolescent disorders

  • Baribeau D
  • Anagnostou E
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Abstract

Autism spectrum disorder is often comorbid with behavioral disturbances such as irritability, aggression and hyperactivity. Throughout the mid 2000s, several large-scale controlled clinical trials were published leading to the approval of two medications (aripiprazole and risperidone) for treatment of irritability in this condition. This review serves as an update regarding new research findings regarding psychopharmacology for children and adolescents with ASD. In summary, the past five years have yielded no further approved medications with ASD as a primary indication. Important new research results include 1) long-term safety and efficacy data (52 week) regarding treatment with aripiprazole for irritability, 2) consensus regarding potential harm from SSRIs for treatment of repetitive behaviors in children/ adolescents with ASD, 3) a randomized controlled trial showing modest benefits from atomoxetine on hyperactivity, 4) many novel agents currently under investigation. © 2014 Springer Science+Business Media New York.

Author-supplied keywords

  • *autism
  • *behavior disorder/dt [Drug Therapy]
  • *behavior disorder/si [Side Effect]
  • *psychopharmacotherapy
  • acetylcysteine/dt [Drug Therapy]
  • aggression
  • amantadine/dt [Drug Therapy]
  • anger
  • anticonvulsive agent/ct [Clinical Trial]
  • anticonvulsive agent/dt [Drug Therapy]
  • antidepressant agent/dt [Drug Therapy]
  • aripiprazole/ae [Adverse Drug Reaction]
  • aripiprazole/cm [Drug Comparison]
  • aripiprazole/ct [Clinical Trial]
  • aripiprazole/do [Drug Dose]
  • aripiprazole/dt [Drug Therapy]
  • arousal
  • article
  • atomoxetine/ae [Adverse Drug Reaction]
  • atomoxetine/ct [Clinical Trial]
  • atomoxetine/dt [Drug Therapy]
  • attention deficit disorder/dt [Drug Therapy]
  • automutilation/dt [Drug Therapy]
  • automutilation/si [Side Effect]
  • body weight disorder/si [Side Effect]
  • celecoxib/dt [Drug Therapy]
  • cholesterol blood level
  • citalopram/ae [Adverse Drug Reaction]
  • citalopram/ct [Clinical Trial]
  • citalopram/dt [Drug Therapy]
  • clomipramine/ae [Adverse Drug Reaction]
  • clomipramine/ct [Clinical Trial]
  • clomipramine/dt [Drug Therapy]
  • clonidine/ae [Adverse Drug Reaction]
  • clonidine/ct [Clinical Trial]
  • clonidine/dt [Drug Therapy]
  • compulsion/dt [Drug Therapy]
  • constipation/si [Side Effect]
  • decreased appetite/si [Side Effect]
  • diarrhea/si [Side Effect]
  • dose response
  • drowsiness/si [Side Effect]
  • drug dose titration
  • drug efficacy
  • drug hypersensitivity/si [Side Effect]
  • drug indication
  • drug megadose
  • drug safety
  • drug tolerability
  • drug withdrawal
  • dry skin/si [Side Effect]
  • emotion
  • enuresis/si [Side Effect]
  • etiracetam/ct [Clinical Trial]
  • etiracetam/dt [Drug Therapy]
  • extrapyramidal syndrome/si [Side Effect]
  • fatigue/si [Side Effect]
  • fenfluramine/ct [Clinical Trial]
  • fenfluramine/dt [Drug Therapy]
  • fluoxetine/ae [Adverse Drug Reaction]
  • fluoxetine/ct [Clinical Trial]
  • fluoxetine/dt [Drug Therapy]
  • fluvoxamine/ct [Clinical Trial]
  • fluvoxamine/dt [Drug Therapy]
  • galantamine/dt [Drug Therapy]
  • guanfacine/ae [Adverse Drug Reaction]
  • guanfacine/ct [Clinical Trial]
  • guanfacine/dt [Drug Therapy]
  • haloperidol/ae [Adverse Drug Reaction]
  • haloperidol/cm [Drug Comparison]
  • haloperidol/ct [Clinical Trial]
  • haloperidol/dt [Drug Therapy]
  • human
  • hyperactivity/dt [Drug Therapy]
  • hyperactivity/si [Side Effect]
  • hyperprolactinemia/si [Side Effect]
  • hypersalivation/si [Side Effect]
  • impulsiveness
  • increased appetite/si [Side Effect]
  • insomnia/si [Side Effect]
  • irritability
  • lamotrigine/ct [Clinical Trial]
  • lamotrigine/dt [Drug Therapy]
  • loss of appetite/si [Side Effect]
  • mental concentration
  • metabolic disorder/si [Side Effect]
  • methylphenidate/ae [Adverse Drug Reaction]
  • methylphenidate/ct [Clinical Trial]
  • methylphenidate/do [Drug Dose]
  • methylphenidate/dt [Drug Therapy]
  • nausea/si [Side Effect]
  • neuroleptic agent/dt [Drug Therapy]
  • nose obstruction/si [Side Effect]
  • piracetam/dt [Drug Therapy]
  • placebo
  • propranolol/dt [Drug Therapy]
  • pruritus/si [Side Effect]
  • psychosocial withdrawal
  • riluzole/dt [Drug Therapy]
  • risperidone/ae [Adverse Drug Reaction]
  • risperidone/cm [Drug Comparison]
  • risperidone/ct [Clinical Trial]
  • risperidone/dt [Drug Therapy]
  • sedation
  • serotonin uptake inhibitor/ae [Adverse Drug Reacti
  • serotonin uptake inhibitor/dt [Drug Therapy]
  • side effect/si [Side Effect]
  • sleep disorder/si [Side Effect]
  • somnolence/si [Side Effect]
  • stereotypy
  • tianeptine/ct [Clinical Trial]
  • tianeptine/dt [Drug Therapy]
  • tremor/si [Side Effect]
  • triacylglycerol blood level
  • unindexed drug
  • unspecified side effect/si [Side Effect]
  • valproate semisodium/ct [Clinical Trial]
  • valproate semisodium/dt [Drug Therapy]
  • valproic acid/ct [Clinical Trial]
  • valproic acid/dt [Drug Therapy]
  • vomiting/si [Side Effect]
  • weight gain
  • weight reduction
  • xerostomia/si [Side Effect]

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Authors

  • D A Baribeau

  • E Anagnostou

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