Uptake, depuration, and radiation dose estimation in zebrafish exposed to radionuclides via aqueous or dietary routes

  • Reinardy H
  • Teyssie J
  • Jeffree R
 et al. 
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Understanding uptake and depuration of radionuclides in organisms is necessary to relate exposure to radiation dose and ultimately to biological effects. We investigated uptake and depuration of a mixture of radionuclides to link bioaccumulation with radiation dose in zebrafish, Danio rerio. Adult zebrafish were exposed to radionuclides (54Mn,60Co,65Zn,75Se,109Cd,110mAg,134Cs and241Am) at tracer levels (65Zn>109Cd>110mAg>54Mn>60Co>241Am>134Cs (range: 175-8Bqg1). After dietary exposure the order of radionuclide activity concentration in tissues (Bqg-1) was:65Zn>60Co>75Se>109Cd>110mAg>241Am>54Mn>134Cs (range: 91-1Bqg-1). Aqueous exposure resulted in higher whole body activity concentrations for all radionuclides except60Co. Route of exposure did not appear to influence activity concentrations in gonads, except for54Mn,65Zn, and75Se, which had higher activity concentrations in gonads following aqueous exposure. Highest gonad activity concentrations (Bqg-1) were for75Se (211),109Cd (142), and65Zn (117), and highest dose rates (-Gyh-1) were from241Am (aqueous, 1050; diet 242). This study links radionuclide bioaccumulation data obtained in laboratory experiments with radiation dose determined by application of a dosimetry modelling tool, an approach that will enable better linkages to be made between exposure, dose, and effects of radionuclides in organisms. © 2011 Elsevier B.V.

Author-supplied keywords

  • Bioaccumulation
  • ERICA Tool\
  • Radiation dosimetry
  • Radionuclides
  • Zebrafish

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