Uric acid, left ventricular mass index, and risk of cardiovascular disease in essential hypertension.

  • Iwashima Y
  • Horio T
  • Kamide K
 et al. 
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Abstract

Elevated serum uric acid (UA) is frequently encountered in individuals with hypertension, but whether the relationship between UA and cardiovascular events is circumstantial or causal remains to be answered. We examined the association between serum UA and left ventricular mass index (LVMI) and investigated prospectively whether the combination of UA and LVMI can predict the incidence of cardiovascular disease (CVD) in asymptomatic subjects with essential hypertension. A total of 619 subjects (mean age, 61 years; 52% female) free of prior CVD were included in this study. A significant association between UA and LVMI was also confirmed in multiple regression analysis (male: F=4.29, P126.9, female: >112.0 g/m2; UA, male: >374.7, female: >303.3 micromol/L; log-rank chi2=13.18; P

Author-supplied keywords

  • Cardiovascular Diseases
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Heart Ventricles
  • Humans
  • Hypertension
  • Incidence
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Proportional Hazards Models
  • Prospective Studies
  • Regression Analysis
  • Risk Factors
  • Survival Analysis
  • Uric Acid
  • blood
  • complications
  • diagnostic imaging
  • epidemiology
  • etiology

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Authors

  • Yoshio Iwashima

  • Takeshi Horio

  • Kei Kamide

  • Hiromi Rakugi

  • Toshio Ogihara

  • Yuhei Kawano

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