Urinary albumin: Creatinine ratio (ACR) and the prediction of postoperative complications after abdominal aortic aneurysm repair

  • M.G.A. N
  • R.D. S
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Introduction: Open repair of abdominal aortic aneurysm (AAA) requires aortic clamping. This results in an ischaemia-reperfusion injury (IRI) which can lead to the development of the systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF). We investigated the use of urinary albumin:creatinine ratio (ACR) as a simple predictor of the development of complications (SIRS) postoperatively. Methods: Forty-four patients undergoing elective infrarenal AAA repair and 10 control patients undergoing major abdominal surgery had fresh urine samples taken before, immediately after and 24 h after the procedure. Urinary ACR was calculated on all samples, and daily SIRS scores were calculated for all patients postoperatively. Systemic interleukin-6 (IL-6) levels were measured intraoperatively to measure the cytokine response to surgery. Results: AAA patients demonstrated a characteristic pattern of ACR levels during the three time points, with a significant increase in the ACR immediately postoperatively and with normalisation by 24 h (P

Author-supplied keywords

  • Wilcoxon signed ranks test
  • abdominal aorta aneurysm
  • albumin
  • aneurysm surgery
  • aorta clamping
  • aorta surgery
  • article
  • clinical article
  • controlled study
  • correlation analysis
  • creatinine
  • creatinine urine level
  • human
  • interleukin 6
  • multiple organ failure
  • patient monitoring
  • peroperative care
  • postoperative care
  • postoperative complication
  • priority journal
  • prognosis
  • protein blood level
  • proteinuria
  • reperfusion injury
  • scoring system
  • surgical technique
  • systemic inflammatory response syndrome
  • urinalysis

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  • Norwood M.G.A.

  • Sayers R.D.

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