Validation of a bioelectrical impedance analysis equation to predict appendicular skeletal muscle mass (ASMM)

  • Kyle U
  • Genton L
  • Hans D
 et al. 
  • 55


    Mendeley users who have this article in their library.
  • 67


    Citations of this article.


Rationale: Appendicular skeletal muscle mass (ASMM) is useful in the evaluation of nutritional status because it reflects the body muscle protein mass. The purpose of this study was to validate, against dual-energy X-ray absorptiometry (DEXA), a BIA equation to predict ASMM to be used in volunteers and patients. Method: Healthy men (n = 246 men, BMI 25.3 ±2.9 kg/m2) and women (n =198, 24.1 ± 3.6 kg/m2), and heart, lung and liver transplant patients (213 men, BMI of 24.6 ± 4.4 kg/m2; 113 women, BMI 23.0 + 5.2 kg/m2) were measured by BIA (Xitron Technologies) and DEXA (Hologic QDR 4500). A BIA equation to predict ASMM (kg) that included height2/resistance, weight, gender, age and reactance, was developed by means of multiple regressions. Results: A table is presented. Mean ± SD, paired t-test between BIA and DXA P < 0.01 Mean difference (Bland-Altman) for volunteers was 0.1 ± 1.1 kg, r=0.95, SEE 1.12 kg and for patients - 0.4 ± 1.5 kg, r=0.91, SEE 1.5 kg. Best fitted multiple regression equation was -4.211 + (0.267 × height2 / resistance) + (0.095 × weight) + (1.909 × sex (men = 1, women = 0)) + (-0.012 × age) + (0.058 × reactance). Conclusions: BIA permits the prediction of ASMM in healthy volunteers and patients between 22 and 94 years of age. A slightly larger, though clinically not significant, error was noted in patients. © 2003 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Appendicular skeletal muscle mass
  • Bioelectrical impedance analysis
  • Dual X-ray absorptiometry
  • Validation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Didier HansCenter of Bone Diseases, Lausanne University Hospital

  • U. G. Kyle

  • L. Genton

  • C. Pichard

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free