A validation framework for probabilistic maps using Heschl's gyrus as a model

  • Tahmasebi A
  • Abolmaesumi P
  • Wild C
 et al. 
  • 38

    Readers

    Mendeley users who have this article in their library.
  • 4

    Citations

    Citations of this article.

Abstract

Probabilistic maps are useful in functional neuroimaging research for anatomical labeling and for data analysis. The degree to which a probability map can accurately estimate the location of a structure of interest in a new individual depends on many factors, including variability in the morphology of the structure of interest over subjects, the registration (normalization procedure and template) applied to align the brains among individuals for constructing a probabilitymap, and the registration used tomap a new subject's data set to the frame of the probabilistic map. Here, we take Heschl's gyrus (HG) as our structure of interest, and explore the impact of different registration methods on the accuracy with which a probabilistic map of HG can approximate HG in a new individual. We assess and compare the goodness of fit of probability maps generated using five different registration techniques, as well as evaluating the goodness of fit of a previously published probabilistic map of HG generated using affine registration (Penhune et al., 1996). The five registration techniques are: three groupwise registration techniques (implicit reference-based or IRG, DARTEL, and BSpline-based); a high-dimensional pairwise registration (HAMMER) as well as a segmentation-based registration (unified segmentation of SPM5). The accuracy of the resulting maps in labeling HG was assessed using evidence-based diagnostic measures within a leave-one-out crossvalidation framework. Our results demonstrated the out performance of IRG and DARTEL compared to other registration techniques in terms of sensitivity, specificity and positive predictive value (PPV). All the techniques displayed relatively low sensitivity rates, despite high PPV, indicating that the generated probability maps provide accurate but conservative estimates of the location and extent of HG in new individuals. © 2009 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • BSpline-based groupwise
  • DARTEL
  • Goodness of fit
  • Groupwise registration
  • HAMMER
  • Heschl's gyrus
  • Implicit reference-based groupwise
  • Overlap measure
  • Pairwise registration
  • Positive predictive value
  • Primary auditory cortex
  • Probabilistic map
  • Sensitivity
  • Specificity
  • Unified segmentation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free