Value of information and value of implementation: application of an analytic framework to inform resource allocation decisions in metastatic hormone-refractory prostate cancer

  • Hoomans T
  • Fenwick E
  • Palmer S
 et al. 
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Abstract

In a budget-constrained health-care system, decisions about investing in strategies to promote implementation have to be made alongside decisions about health-care provision and research funding. Using a Bayesian decision-theoretic approach, an analytic framework has been developed to inform these separate but related decisions, establishing the expected value of both perfect information (EVPI) and perfect implementation (EVPIM). We applied this framework to inform decision-making about resource allocation to metastatic hormone-refractory prostate cancer (mHRPC) in the UK.

Author-supplied keywords

  • Antineoplastic Agents
  • Antineoplastic Agents: economics
  • Antineoplastic Agents: therapeutic use
  • Bayes Theorem
  • Bone Density Conservation Agents
  • Bone Density Conservation Agents: economics
  • Bone Density Conservation Agents: therapeutic use
  • Clodronic Acid
  • Clodronic Acid: economics
  • Clodronic Acid: therapeutic use
  • Cost-Benefit Analysis
  • Decision Making
  • Decision Support Techniques
  • Economic
  • Glucocorticoids
  • Glucocorticoids: economics
  • Glucocorticoids: therapeutic use
  • Great Britain
  • Health Resources
  • Health Resources: economics
  • Health Resources: utilization
  • Hormonal
  • Hormonal: economics
  • Hormonal: therapeutic use
  • Humans
  • Male
  • Mitoxantrone
  • Mitoxantrone: economics
  • Mitoxantrone: therapeutic use
  • Models
  • Monte Carlo Method
  • Prednisolone
  • Prednisolone: economics
  • Prednisolone: therapeutic use
  • Prednisone
  • Prednisone: economics
  • Prednisone: therapeutic use
  • Prostatic Neoplasms
  • Prostatic Neoplasms: drug therapy
  • Prostatic Neoplasms: economics
  • Prostatic Neoplasms: pathology
  • Quality-Adjusted Life Years
  • Resource Allocation
  • Resource Allocation: economics
  • State Medicine
  • Taxoids
  • Taxoids: economics
  • Taxoids: therapeutic use
  • Treatment Failure

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Authors

  • Ties Hoomans

  • Elisabeth a L Fenwick

  • Steve Palmer

  • Karl Claxton

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