Var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2

  • Albrecht L
  • Moll K
  • Blomqvist K
 et al. 
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Abstract

The pathogenicity of Plasmodium falciparum is in part due to the ability of the parasitized red blood cell (pRBC) to adhere to intra-vascular host cell receptors and serum-proteins. Binding of the pRBC is mediated by Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a large multi-variant molecule encoded by a family of ≈60 var genes.

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Authors

  • Letusa Albrecht

  • Kirsten Moll

  • Karin Blomqvist

  • Johan Normark

  • Qijun Chen

  • Mats Wahlgren

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