Venous thromboembolism: risk factors for recurrence

  • Zhu T
  • Martinez I
  • Emmerich J
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Patients who have a first episode of venous thromboembolism (VTE) have an elevated risk of a recurrent episode, and this necessitates secondary prophylaxis. Anticoagulant therapy is a double-edged sword, however, as it reduces the risk of recurrent VTE but increases the risk of hemorrhage. This balance must be taken into account when assessing the risk-benefit ratio of long-term anticoagulation. Some clinical characteristics of the index VTE event can help to categorize the individual risk of recurrence. Patients with persistent risk factors such as cancer have a significantly higher risk of recurrent thrombosis. In contrast, VTE provoked by transient risk factors is associated with a lower risk of recurrence. Intrinsic features of patients with VTE (gender, age, hereditary thrombophilia) have also been linked to the risk of recurrent VTE. There is increasing evidence that a normal D-dimer level and the absence of residual venous thrombosis after discontinuation of oral anticoagulation are associated with a lower risk of recurrent VTE events. Future studies are needed to refine the predictive value of known risk factors for VTE recurrence and to discover better markers

Author-supplied keywords

  • Administration,Oral
  • Age Factors
  • Anticoagulants
  • Antiphospholipid Syndrome
  • Biological Markers
  • Drug Administration Schedule
  • Female
  • Fibrin
  • Fibrin Fibrinogen Degradation Products
  • Fibrinogen
  • France
  • Hemorrhage
  • Humans
  • Male
  • Neoplasms
  • Predictive Value of Tests
  • Pulmonary Embolism
  • Recurrence
  • Risk
  • Risk Assessment
  • Risk Factors
  • Sex Factors
  • Thrombin
  • Thromboembolism
  • Thrombophilia
  • Thrombosis
  • Treatment Outcome
  • Venous Thromboembolism
  • Venous Thrombosis
  • administration & dosage
  • adverse effects
  • blood
  • chemically induced
  • complications
  • drug therapy
  • ethnology
  • etiology
  • metabolism
  • prevention & control
  • therapeutic use
  • therapy

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  • PMID: 19228602


  • T Zhu

  • I Martinez

  • J Emmerich

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