Vertical Toxoplasmosis in a Murine Model. Protection after Immunization with Antigens of Toxoplasma gondii Incorporated into Liposomes

  • Elsaid M
  • Martins M
  • Frézard F
 et al. 
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Abstract

Distinct Toxoplasma gondii antigens were entrapped within liposomes and evaluated for their ability to protect Balb/c mice against congenital transmission: soluble tachyzoite antigen (L/STAg), soluble tissue cyst antigen (L/SCAg), soluble tachyzoite plus tissue cyst (L/STCAg) or purified 32kDa antigen of tachyzoite (L/pTAg). Soluble tachyzoite antigen alone in PBS (STAg) or emulsified in Freund's Complete Adjuvant (FCA/STAg) was also evaluated. Dams were inoculated subcutaneously with these antigens 6, 4 and 2 weeks prior to a challenge with four tissue cysts of the P strain of T. gondii orally between 10 and 14 days of pregnancy. Significant diminution differences were observed between the frequency of infected pups born of the dams immunized with the antigens incorporated into liposomes and that of pups born of the dams immunized with antigen emulsified in FCA or non immunized group (p

Author-supplied keywords

  • Congenital transmission
  • Immunoprotection
  • Liposomes
  • Mice
  • Toxoplasma

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Authors

  • Erika BragaUniversidade Federal de Minas Gerais

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  • Mohamed M.A. Elsaid

  • Maria S. Martins

  • Frédéric Frézard

  • Ricardo W.A. Vitor

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