Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNA destabilization.

  • Myer V
  • Lee S
  • Steitz J
  • 12


    Mendeley users who have this article in their library.
  • 51


    Citations of this article.


Herpesvirus saimiri (HVS) is one of several primate viruses that carry genes for small RNAs. The five H. saimiri-encoded U RNAs (HSURs) are the most abundant viral transcripts expressed in transformed marmoset T lymphocytes. They assemble with host proteins common to spliceosomal small nuclear ribonucleoproteins (snRNPs). HSURs 1, 2, and 5 exhibit sequences at their 5' ends identical to the AUUUA motif, which targets a number of protooncogene, cytokine, and lymphokine mRNAs for rapid degradation. We show that a 32-kDa protein previously demonstrated to bind to the 3' untranslated region of several unstable messages can be UV crosslinked specifically to HSUR 1, 2, and 5 transcripts in vitro, as well as to endogenous HSUR snRNPs. Our results suggest an unusual role for these viral snRNPs: HSURs may function to attenuate the rapid degradation of certain cellular mRNAs, thereby facilitating viral transformation of host T lymphocytes.

Author-supplied keywords

  • Base Sequence
  • Binding Sites
  • Cloning, Molecular
  • Herpesvirus 2, Saimiriine
  • Herpesvirus 2, Saimiriine: genetics
  • Molecular Sequence Data
  • Nuclear Proteins
  • Nuclear Proteins: metabolism
  • Protein Binding
  • RNA, Messenger
  • RNA, Messenger: metabolism
  • RNA, Viral
  • RNA, Viral: metabolism
  • Ribonucleoproteins
  • Ribonucleoproteins, Small Nuclear
  • Ribonucleoproteins: metabolism
  • Ribonucleoproteins: radiation effects
  • Ultraviolet Rays

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • V E Myer

  • S I Lee

  • J a Steitz

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free