Introduction: Sertoli-Leydig cell tumors (SLCTs) are rare tumors mostly occurring in young women. Here we report an unusual case of a SLCT with simultaneous occurrence of endometrioid adenocarcinoma of the endometrium in a woman in menopause. Case report: A 67-year-old woman presented with progressive signs of virilization. Blood tests showed increased levels of testosterone, delta-4-androstenedione, and dehydroepiandrosterone (DHEA). DHEA-sulphate, 17β-estradiol, estrone, and sex-hormone binding globulin serum levels were within the normal range. Magnetic resonance imaging revealed a solid mass of 2.7 × 2.9 cm in the right ovary set against the background of the uterus. The patient underwent bilateral salpingo-oophoretomy with hysterectomy. The mass in the right ovary was a differentiated SLCT. Incidentally, the endometrium revealed an endometrioid adenocacinoma. Following surgical treatment the plasma androgens dropped to normal levels, and signs and symptoms of virilization improved. Conclusion: SLCT should be suspected in postmenopausal women who present rapid progressive androgen excess symptoms with hyperandrogenemia. © the author(s), publisher and licensee Libertas Academica Ltd.
CITATION STYLE
Di Giacinto, P., Chioma, L., Vancieri, G., Guccione, L., Cicerone, E., Ulisse, S., … Moretti, C. (2012). Virilizing Leydig-Sertoli cell ovarian tumor associated with endometrioid carcinoma of the endometrium in a postmenopausal patient: Case report and general considerations. Clinical Medicine Insights: Case Reports, 5, 149–153. https://doi.org/10.4137/CCRep.S10555
Mendeley helps you to discover research relevant for your work.