Visual and auditory hallucinations with excessive intake of paroxetine [1]

  • Kumagai R
  • Ohnuma T
  • Nagata T
 et al. 
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Letter to the editor discussing a case report of a patient without organic factors, in which hallucinations were experienced during treatment with paroxetine, a selective serotonin re-uptake inhibitor (SSRI). The patient was a 28-year-old Japanese woman diagnosed with dissociative disorder and had experienced symptoms of dissociation since she was 25 years of age. After 1 month of a self-prescribed increase of paroxetine, during her treatment with the same drug, she experienced hallucinations. Her doctor discontinued her treatment with paroxetine. After 4 days the patient was unable to control her temper and experienced hallucinations and was admitted to Juntendo Koshigaya Hospital. Twelve days after the administration of sultopride the symptoms disappeared. The present patient had no brain damage and neurodegenerative disorders were completely excluded. Therefore, the excessive intake of paroxetine may be a possible cause for the hallucinations our patient experienced. The paroxetine may induce excessive serotonergic neurotransmission, resulting in the imbalance of the serotonergic/cholinergic system, and finally producing the hallucinations. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

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  • Ryo Kumagai

  • Tohru Ohnuma

  • Toshihiko Nagata

  • Heii Arai

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