Visual distortion provoked by a stimulus in migraine associated with hyperneuronal activity

  • Huang J
  • Cooper T
  • Satana B
 et al. 
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Abstract

BACKGROUND: Migraineurs with visual aura are highly susceptible to illusions and visual distortion and are particularly sensitive to a pattern of regularly spaced parallel lines or stripes. PURPOSE: To determine whether the high degree of susceptibility to illusions and visual distortion in migraineurs with aura is associated with hyperneurological activity of the occipital cortex. METHODS: In order to investigate any relationships among neuronal activity, spatial frequency of square-wave gratings, and self-described visual distortion, we investigated the neuronal and psychophysical responses to square-wave gratings in migraineurs with visual aura and in nonheadache controls. RESULTS: Square-wave gratings provoked various types of visual distortion and illusions and induced a hyperneuronal response in the visual cortex of migraineurs with visual aura, a response that strongly depended upon the stimulus spatial frequency. CONCLUSION: The hyperneuronal activity of the occipital cortex is consistent with general cortical hyperexcitability in migraine.

Author-supplied keywords

  • Functional MRI
  • Migraine
  • Visual activation
  • Visual distortion

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Authors

  • Jie Huang

  • Thomas G. Cooper

  • Banu Satana

  • David I. Kaufman

  • Yue Cao

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