Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract.

  • Gugatschka M
  • Kiesler K
  • Obermayer-Pietsch B
 et al. 
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Abstract

Considerable clinical and experimental data suggest that vitamin D plays a role in pathogenesis and progression of cancer; nevertheless clinical data for head and neck squamous cell carcinoma (HNSCC) are not available. The aim of our study was to associate tumor and clinical characteristics with status of vitamin D [25-hydroxyvitamin D (25(OH)D)]. 88 patients with newly diagnosed squamous cell carcinoma of the head and neck were included in the study. A blood draw was taken at the time of diagnosis. The observation period lasted from 2006 until 2010. Results: When compared to a cohort from an epidemiological study, serum levels of 25(OH)D were significantly reduced in patients with HNSCC. We furthermore found disease-free survival, as well as overall survival times to be significantly associated with 25(OH)D levels. In conclusion, results from our study suggest an influence of vitamin D status on cancer incidence, as well as on mortality of HNSCC.

Author-supplied keywords

  • Aged
  • Austria
  • Austria: epidemiology
  • Carcinoma, Squamous Cell
  • Carcinoma, Squamous Cell: blood
  • Carcinoma, Squamous Cell: mortality
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Head and Neck Neoplasms
  • Head and Neck Neoplasms: blood
  • Head and Neck Neoplasms: mortality
  • Humans
  • Male
  • Middle Aged
  • Morbidity
  • Morbidity: trends
  • Prognosis
  • Retrospective Studies
  • Survival Rate
  • Survival Rate: trends
  • Time Factors
  • Tumor Markers, Biological
  • Tumor Markers, Biological: blood
  • Vitamin D
  • Vitamin D: blood

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Authors

  • Markus Gugatschka

  • Karl Kiesler

  • Barbara Obermayer-Pietsch

  • Andrea Groselj-Strele

  • Antonia Griesbacher

  • Gerhard Friedrich

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