The Use of Vitamin a in Pre???Menstrual Tension

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Vitamin A has often been used with success in the treatment of pre-menstrual pain.The beneficial effect of the vitamin in such cases was accidentally discovered by Simkins in 1947, following administration of the substance to a patient for the treatment of hyperthyroidism.The underlying mechanism of the effect of vitamin A on pre-menstrual pain is not properly understood.It has been assumed that it reduces the thyroid hyperactivity and the accompanying increased tone of the sympathetic nervous system, which often exists pre-menstrually.This effect is said to be due to inactivation of thyroxin by carotene.It has also been supposed that vitamin A participates in the inactivation of oestrogen in the liver and thereby counteracts pre-menstrual hyper-oestrogenism.Some authors have also assumed that it has a direct anti-oestrogenic effect.Vitamin A participates in the formation of visual purple.Night-blindness, which is apt to occur in vitamin A deficiency, has been described as common in the pre-menstrual phase.

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