In vitro activity of linezolid against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae

  • Patel R
  • Rouse M
  • Piper K
 et al. 
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Abstract

We report the activity of the new oxazolidinone antimicrobial agent linezolid against 37 clinical isolates of vancomycin-resistant enterococci (including organisms carrying the vanA, vanB, vanC-1, and vanC-2/3 genes), 26 clinical isolates of methicillin-resistant S. aureus and 20 clinical isolates of high-level penicillin-resistant S. pneumoniae. All isolates of vancomycin-resistant enterococci were inhibited by < or = 4 ug/ml of linezolid. All isolates of methicillin-resistant S. aureus were inhibited by < or = 8 ug/ml of linezolid. All isolates of penicillin-resistant S. pneumoniae were inhibited by < or = 2 ug/ml of linezolid. Linezolid inhibits strains of multidrug resistant Gram-positive cocci in vitro at concentrations < or = 8 ug/ml.

Author-supplied keywords

  • *Oxazolidinones
  • Acetamides/*pharmacology
  • Anti-Bacterial Agents/*pharmacology
  • Drug Resistance, Microbial/genetics
  • Enterococcus/*drug effects
  • Gram-Positive Bacterial Infections/microbiology
  • Humans
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Oxazoles/*pharmacology
  • Penicillin Resistance
  • Pneumococcal Infections/microbiology
  • Staphylococcal Infections/microbiology
  • Staphylococcus aureus/*drug effects
  • Streptococcus pneumoniae/*drug effects
  • Vancomycin/pharmacology

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Authors

  • R Patel

  • M S Rouse

  • K E Piper

  • J M Steckelberg

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