In Vitro Comparison of Active and Passive Physiological Control Systems for Biventricular Assist Devices

  • Pauls J
  • Stevens M
  • Schummy E
 et al. 
  • 13

    Readers

    Mendeley users who have this article in their library.
  • 4

    Citations

    Citations of this article.

Abstract

The low preload and high afterload sensitivities of rotary ventricular assist devices (VADs) may cause ventricular suction events or venous congestion. This is particularly problematic with rotary biventricular support (BiVAD), where the Starling response is diminished in both ventricles. Therefore, VADs may benefit from physiological control systems to prevent adverse events. This study compares active, passive and combined physiological controllers for rotary BiVAD support with constant speed mode. Systemic (SVR) and pulmonary (PVR) vascular resistance changes and exercise were simulated in a mock circulation loop to evaluate the capacity of each controller to prevent suction and congestion and increase exercise capacity. All controllers prevented suction and congestion at high levels of PVR (900 dynes s cm−5) and SVR (3000 dynes s cm−5), however these events occurred in constant speed mode. The controllers increased preload sensitivity (0.198–0.34 L min−1 mmHg−1) and reduced afterload sensitivity (0.0001–0.008 L min−1 mmHg−1) of the VADs when compared to constant speed mode (0.091 and 0.072 L min−1 mmHg−1 respectively). The active controller increased pump speeds (400–800 rpm) and pump flow by 2.8 L min−1 during exercise, thus increasing exercise capacity. By reducing suction and congestion and by increasing exercise capacity, the control systems presented in this study may help increase quality of life of VAD patients.

Author-supplied keywords

  • Active control
  • Passive control
  • Physiological control
  • Ventricular assist devices
  • Ventricular suction prevention

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free