In vitro and in vivo evaluation of docetaxel loaded biodegradable polymersomes

  • Upadhyay K
  • Bhatt A
  • Castro E
 et al. 
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Abstract

Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and showed controlled release behaviour over several days. PolyDOC showed high in vitro toxicity after 24 h in MCF-7 and U87 cells compared to free DOC. Biodistribution data demonstrated that (99m)Tc labelled PolyDOC t(1/2) and MRT significantly increased compared to a DOC solution (DS). In addition, PolyDOC uptake in Ehrlich Ascites Tumor (EAT) tumor bearing mice was larger at each time point compared to DS, making such a polymer vesicle formulation an efficient drug nanocarrier for improved DOC cancer therapy.

Author-supplied keywords

  • Biodegradable
  • Biodistribution
  • Docetaxel
  • Drug delivery systems
  • Hyaluronan
  • Polymersome
  • Tumor uptake

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