A wave dynamics criterion for optimization of mammalian cardiovascular system

  • Pahlevan N
  • Gharib M
  • 19


    Mendeley users who have this article in their library.
  • 3


    Citations of this article.


The cardiovascular system in mammals follows various optimization criteria covering the heart, the vascular network, and the coupling of the two. Through a simple dimensional analysis we arrived at a non-dimensional number (wave condition number) that can predict the optimum wave state in which the left ventricular (LV) pulsatile power (LV workload) is minimized in a mammalian cardiovascular system. This number is also universal among all mammals independent of animal size maintaining a value of around 0.1. By utilizing a unique in vitro model of human aorta, we tested our hypothesis against a wide range of aortic compliance (pulse wave velocity). We concluded that the optimum value of the wave condition number remains to be around 0.1 for a wide range of aorta compliance that we could simulate in our in-vitro system. © 2014 Elsevier Ltd.

Author-supplied keywords

  • Aorta
  • Arterial wave reflection
  • Hemodynamics
  • Left ventricular workload
  • Mammalian cardiovascular system
  • Optimum heart rate

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free