Whole genome comparison of the A. fumigatus family

  • Wortman J
  • Fedorova N
  • Crabtree J
 et al. 
  • 25


    Mendeley users who have this article in their library.
  • 35


    Citations of this article.


The availability of the genome sequences of multiple Aspergillus spp. presents the research community with an unprecedented opportunity for discovery. The genomes of Neosartorya fischeri and Aspergillus clavatus have been sequenced in order to extend our knowledge of Aspergillus fumigatus, the primary cause of invasive aspergillosis. Through comparative genomic analysis, we hope to elucidate both obvious and subtle differences between genomes, developing new hypotheses that can be tested in the laboratory. A preliminary examination of the genomes and their predicted proteomes reveals extensive conservation between protein sequences and significant synteny, or conserved gene order. Comparative genomic analysis at the level of these closely related aspergilli should provide important insight into the evolutionary forces at play and their effect on gene content, regulation and expression

Author-supplied keywords

  • Aspergillosis
  • Aspergillus
  • Genome
  • Synteny

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • J. R. Wortman

  • N. Fedorova

  • J. Crabtree

  • V. Joardar

  • R. Maiti

  • B. J. Haas

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free