In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator. © 2012 Siggs et al.
CITATION STYLE
Siggs, O. M., Li, X., Xia, Y., & Beutler, A. B. (2012). ZBTB1 is a determinant of lymphoid development. Journal of Experimental Medicine, 209(1), 19–27. https://doi.org/10.1084/jem.20112084
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