Intravenous immunoglobulin therapy is useful against various immune system disorders and viral infections. It is generally safe, and serious adverse reactions are uncommon. We report a rare case of acute encephalopathy following intravenous immunoglobulin therapy for human herpes virus 6 infection in a child. MR imaging findings suggest that the dominant causative mechanism of acute encephalopathy is cytotoxic edema, and the findings indicate 2 primary mechanisms. Reversibility of the restriction of water diffusion (low apparent diffusion coefficient value) on diffusion-weighted MR imaging suggests intramyelinic edema in the myelin sheath, and an increase of glutamate and glutamine complex peak on MR spectroscopy suggests excitotoxic injury to the neurons and astrocytes. © American Society of Neuroradiology.
CITATION STYLE
Wada, A., Yoshida, R., Oda, K., Fukuba, E., Uchida, N., & Kitagaki, H. (2005). Acute encephalopathy associated with intravenous immunoglobulin therapy. American Journal of Neuroradiology, 26(9), 2311–2315.
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