The anti-ulcer activity of ethanolic extract of Annona squamosa leaves was investigated on aspirin induced ulcer models and pylorus ligation in wistar rats. In both models the common parameter determined was ulcer-index. Ethanolic extract of dosage 50, 100 mg/kg p.o produced significant inhibition of gastric lesions induced by pylorus ligation and aspirin induced ulcers. The extract 50mg/kg & 100mg/kg showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control.This present study indicate that Annona squamosa leaves extract have potential anti ulcer activity in both models. This results may further suggests that ethanolic extract was found to posses antiulcerogenic as well as ulcer healing property,which might be anti secretory activity.
CITATION STYLE
Palanisamy, A., Rajesh, V., Perumal, P., Vamsi, B., Nattraja, J. K. K., & Nadu, T. (2011). ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACT OF ANNONA SQUAMOSA LEAVES. International Standard Serial Number, 4(1), 162–167. Retrieved from www.ijprd.com
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