The effect of the aqueous extract of Plantago ovata (PO) (Plantaginaceae) consisting of a mixture of polysaccharides and glycoside on humoral immune responses was studied. In rabbits, after oral administration of PO (0.5 g/kg) a significant decrease in anti-HD antibody titre was observed in primary response. Intraperitoneal injection of 0.25 g/kg of PO in mice prior to immunisation with sheep red blood cells (SRBC) resulted in a significant decrease in hemagglutinating antibody (HD) titre. Oral administration and intraperitoneal injection of 0.25 and 0.5 g/kg of PO resulted in a significant increase in white blood cells (WBC) and spleen leukocytes counts. The spleen weight also increased with intraperitoneal injection (0.25 and 0.5 g/kg) and oral administration of 0.5 g/kg of PO. Present results indicate that PO can suppress the humoral immune responses, especially in primary immune response. (C) 2000 Elsevier Science Ireland Ltd.
CITATION STYLE
R., R., S., S., & M., K. (2000). The effect of Plantago ovata on humoral immune responses in experimental animals. Journal of Ethnopharmacology. R. Rezaeipoor, Immunology Department, Shaheed Beheshti Univ. of Med. Sci., PO Box 19835-145, Tehran, Iran, Islamic Republic of. E-mail: okhravi@khayam.ut.ac.ir: Elsevier Ireland Ltd. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed5&NEWS=N&AN=2000317018
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