Skip to content

Efficient large scale microwave assisted Mannich reactions using substituted acetophenones

by Fredrik Lehmann, Åke ̊ Pilotti, Kristina Luthman
Molecular Diversity ()
Get full text at journal


A series of substituted acetophenones, paraformaldehyde, and symmetrical dialkylamines were used in microwave enhanced Mannich reactions. Appropriate reaction conditions in terms of choice of solvent, reaction temperature, and reaction time were studied to allow a fast and reproducible production of Mannich bases. Both small (2 mmol) and large scale reactions (40 mmol) were performed successfully, providing a series of substituted Mannich bases in moderate to high yields and high purity.

Cite this document (BETA)

Readership Statistics

13 Readers on Mendeley
by Discipline
85% Chemistry
15% Agricultural and Biological Sciences
by Academic Status
46% Student > Ph. D. Student
31% Student > Bachelor
15% Student > Master
by Country
8% United Kingdom

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in