Endometrial cancer

Abstract

Endometrial cancers are the most common gynaecological malignancies in the UK with approximately 4500 new cases occur each year and the incidence is rising. Increasingly there is evidence-based management and centralized specialist care of women with endometrial cancer. Women with high grade disease, deep myometrial invasion or lymphadenopathy should be managed by specialist gynaecological oncologists as part of a multi-disciplinary team (MDT). Results from important clinical trials now guide the application of surgical and non-surgical treatments. Surgery remains the cornerstone of management with a trend towards increased use of minimal access surgery. Radiotherapy-related morbidity can now be reduced by the more selective use of external beam radiotherapy. There remain several unresolved issues however and it is important that relevant clinical trials are offered to eligible women. Women must have multi-disciplinary input before treatment, so that up-to-date and evidence-based treatments and inclusion in clinical trials can be considered. © 2010 Elsevier Ltd.