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Evaluation of basket and paddle dissolution methods using different performance standards

by Vadlamani K. Prasad, Vinod P. Shah, John Hunt, Edward Purich, Patrick Knight, Bernard E. Cabana
Journal of Pharmaceutical Sciences ()
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Dissolution studies using both basket and paddle methods were carried out to evaluate two prednisone standards. Results of the experiments showed that the USP prednisone calibrator is sensitive to perturbations by the basket method but not to perturbations by the paddle method. However, the National Center for Drug Analysis (NCDA) prednisone performance standard is sensitive to perturbations by the paddle method but not to perturbations by the basket method. These results suggest that no single standard can predict the suitability of the dissolution equipment by the basket and paddle methods.

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