An Exploratory Study of Innovation Effectiveness

Abstract

キシリトールを経口投与、エタノールを静脈内注射した。結果キシリトールはエタノールの排出量、エタノール誘導性の血中の乳酸の濃度の上昇に影響を与えなかった。このことはキシリトールが経口投与では肝臓において濃度が低いことに起因している、またエタノールは血中のキシリトール量を5-10倍に増加した。このことはキシリトールの肝臓における酸化がエタノールを投与することにより阻害されたからと思われる、 The effects of oral administration of xylitol on the rate of ethanol elimination and on the ethanol-induced changes in blood concentrations of lactate and pyruvate were studied in seven healthy male subjects. Xylitol (1.0 g/kg body weight) was administered orally and ethanol (0.8 g/kg body weight) intravenously. In the control experiments glucose was given instead of xylitol. Xylitol had no significant effect on the rate of ethanol elimination or on the ethanol-induced increase in the blood lactate concentration. The ethanol-induced changes in the lactate/pyruvate ratio were not affected by xylitol. It is suggested that the ineffectiveness of xylitol is due to its low concentration in the liver after oral administration. Ethanol induced a 5--10 fold increase in the blood concentration of xylitol. This is most probably due to inhibition of xylitol oxidation in the liver by the ethanol-induced reduction in the hepatic redox state. The clinical significance of this finding is unknown.