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Gas chromatographic headspace analysis of sevoflurane in blood

by Mark T. Watts, Monica Escarzaga, Charles H. Williams
Journal of Chromatography B: Biomedical Sciences and Applications ()
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We have developed a rapid, simple and precise gas chromatographic headspace analysis for sevoflurane in blood which circumvents problems associated with the high volatility and low blood/gas partition coefficient of this anesthetic drug. Blood standards are easily prepared by volumetric addition of a saturated aqueous solution of sevoflurane. Likewise, internal standardization is achieved using a saturated aqueous solution of halothane. Chromatographic conditions are similar to those commonly used for the analysis of blood ethanol. A simple method is also described for the preparation of stable and precise aliquots of quality control materials for this assay. ?? 1992.

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