Skip to content

Genome-wide association studies for common diseases and complex traits

by J Hirschhorn, M Daly
Nature Reviews Genetics ()
Get full text at journal

Abstract

Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care.

Cite this document (BETA)

Readership Statistics

4 Readers on Mendeley
by Discipline
 
50% Agricultural and Biological Sciences
 
50% Medicine and Dentistry
by Academic Status
 
50% Researcher
 
25% Other
 
25% Professor > Associate Professor
by Country
 
25% United States

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in