Skip to content

Human genetic variation and its contribution to complex traits

by K Frazer, S Murray, N Schork, E Topol
Nat Rev Genet ()
Get full text at journal

Abstract

The last few years have seen extensive efforts to catalogue human genetic variation and correlate it with phenotypic differences. Most common SNPs have now been assessed in genome-wide studies for statistical associations with many complex traits, including many important common diseases. Although these studies have provided new biological insights, only a limited amount of the heritable component of any complex trait has been identified and it remains a challenge to elucidate the functional link between associated variants and phenotypic traits. Technological advances, such as the ability to detect rare and structural variants, and a clear understanding of the challenges in linking different types of variation with phenotype, will be essential for future progress.

Cite this document (BETA)

Readership Statistics

3 Readers on Mendeley
by Discipline
 
67% Agricultural and Biological Sciences
 
33% Medicine and Dentistry
by Academic Status
 
67% Researcher
 
33% Professor > Associate Professor
by Country
 
33% Spain

Tags

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in