Skip to content

Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54

by Fulvia Terenzi, Srabani Pal, Ganes C. Sen
Virology ()
Get full text at journal


Mammalian cells respond to virus infection or other viral stresses, such as double-stranded (ds) RNA and interferons (IFN), by robust and rapid induction of viral stress-inducible proteins. The induction and actions of one such protein, the human P56, have been extensively studied. However, little is known about the distantly related mouse proteins, MuP56 and MuP54. Here, we report that, in mouse cells, they could be induced by IFN, dsRNA or Sendai virus infection. MuP56 and MuP54 inhibited protein synthesis in vitro by binding to the "c", but not the "e", subunit of the translation initiation factor, eIF-3. The N-terminal region of the MuP54 was sufficient for inhibiting translation, but it and the corresponding region of MuP56 bound to two different regions of eIF3c. Thus, members of the human and murine P56 family have similar but non-identical functions. ?? 2005 Elsevier Inc. All rights reserved.

Cite this document (BETA)

Readership Statistics

12 Readers on Mendeley
by Discipline
75% Agricultural and Biological Sciences
8% Biochemistry, Genetics and Molecular Biology
8% Medicine and Dentistry
by Academic Status
42% Student > Ph. D. Student
33% Researcher
8% Student > Bachelor
by Country
8% United States

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in