Skip to content

Liposome destabilization induced by the HIV-1 fusion peptide Effect of a single amino acid substitution

by Francisca B. Pereira, Félix M. Goñi, JoséL Nieva
FEBS Letters ()
Get full text at journal


The 23-residue synthetic peptide representing the N-terminus of HIV-1 gp41 is known to induce either leakage or fusion of lipid vesicles depending on the experimental conditions. In this paper we report that a polar amino acid substitution V ??? E at position 2, known to block gp41 activity in vivo, makes the peptide unable to destabilize and/or fuse membranes. Moreover this variant, unlike the parent peptide, is never found in the membrane-associated ?? conformation. ?? 1995.

Cite this document (BETA)

Readership Statistics

9 Readers on Mendeley
by Discipline
67% Agricultural and Biological Sciences
11% Environmental Science
11% Physics and Astronomy
by Academic Status
44% Student > Ph. D. Student
44% Researcher
11% Professor > Associate Professor
by Country
11% United States

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in