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Modulated insulin delivery from glucose sensitive hydrogel dosage forms

by J J Kim, K Park
Journal of Controlled Release ()


Glucose-sensitive hydrogels that undergo sol-gel phase transition were used to develop modulated insulin delivery systems, and insulin release from diffusion-controlled reservoir, diffusion-controlled matrix, and erosion-controlled matrix systems was studied in vitro. Insulin release through the glucose-sensitive hydrogel membrane and from the glucose-sensitive hydrogel matrix was dependent on the glucose concentration in the receptor chamber. As the glucose concentration was increased from 1 to 4 mg/ml, the release rate increased. The insulin release rate decreased as the glucose concentration was reduced to 1 mg/ml. Modulated insulin release was achieved using the glucose-sensitive membrane and matrix systems. The glucose-sensitive erodible system did not show modulated release as the glucose concentration was changed between 1 and 4 mg/ml. (26 refs.) (Abstract by Ellen Katz Neumann.)

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