Photoacoustic tomography (PAT) is probably the fastest-growing area of biomedical imaging technology, owing to its capacity for high-resolution sensing of rich optical contrast in vivo at depths beyond the optical transport mean free path (̃1 mm in humanskin). Existing high-resolution optical imaging technologies, such as confocal microscopy and two-photon microscopy, have had a fundamental impact on biomedicine but cannot reach the penetration depths of PAT. By utilizing low ultrasonic scattering, PAT indirectly improves tissue transparency up to 1000-fold and consequently enables deeply penetrating functional and molecular imaging at high spatial resolution. Furthermore, PAT promises in vivo imaging at multiple length-scales; it can image subcellular organelles to organs with the same contrast origin ? an important application in multiscale systems biology research. © 2009 Macmillan Publishers Limited. All rights reserved.
CITATION STYLE
Wang, L. V. (2009). Multiscale photoacoustic microscopy and computed tomography. Nature Photonics, 3(9), 503–509. https://doi.org/10.1038/nphoton.2009.157
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