Neuropharmacological effects of aqueous leaf extract of Bryophyllum pinnatum in mice

  • Salahdeen H
  • Yemitan O
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Abstract

Effects of aqueous leaf extracts of bryophyllum pinnatum (AEBP) on some neuropharmacological activities were studied in mice. The extract in dosages (50,100 and 200 mg/kg) was found to produce a profound decrease in exploratory activity in a dose-dependent manner. It also showed a marked sedative effect as evidenced by a significant reduction in gross behaviour and potentiation of pentobarbitone-induced sleeping time. It delayed onset in strychnine-and picrotoxin-induced convulsion (seizures) respectively with the protective effect being significantly higher in picrotoxin- than strychnine-induced convulsion. It also decreases the rate of picrotoxin-induced mortality in mice with LD50 of 641mg/kg. The totality of these effects showed that the extract possesses depressant action on the central nervous system

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Salahdeen, H. M., & Yemitan, O. K. (2009). Neuropharmacological effects of aqueous leaf extract of Bryophyllum pinnatum in mice. African Journal of Biomedical Research, 9(2). https://doi.org/10.4314/ajbr.v9i2.48782

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