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Neuroprotective effect of recombinant human erythropoietin on optic nerve injury in rats.

by Hui Wang, Zhe-li Liu, Xiao-tong Zhuang, Min-fang Wang, Li Xu
Chinese medical journal ()
  • ISSN: 0366-6999


Optic nerve injury, caused by retinal and optic nerve diseases, can eventually result in vision loss. To date, few effective treatments have been discovered to restore visual function. Previous studies showed that recombinant human erythropoietin (rhEPO) has a neuroprotective effect on the central nervous system, particularly in nerve injury. In this study, we investigated the effects of rhEPO on axonal regeneration and functional restoration following optic nerve injury. This was done by measuring the expression of growth associated protein 43 (GAP-43), a marker for neuronal regeneration, on the retina and flash-visual evoked potential (F-VEP).

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