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P-Maleimidophenyl Isocyanate: a Novel Heterobifunctional Linker for Hydroxyl To Thiol Coupling.

by M E Annunziato, U S Patel, M Ranade, P S Palumbo
Bioconjugate chemistry ()

Abstract

p-Maleimidophenyl isocyanate (PMPI, 1) is a heterobifunctional cross-linking agent useful for thiol to hydroxyl coupling. Several maleimide-activated compounds were prepared and characterized and then shown to be reactive with thiol-containing proteins. Examples include activation of vitamin B12, digoxigenin, digitoxigenin, estradiol, progesterone, and some serine-containing peptides.

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