Positive and negative associations of HLA class i alleles with allopurinol-induced SCARs in Koreans

194Citations
Citations of this article
45Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Recent investigations suggest genetic susceptibility of allopurinol-induced severe cutaneous adverse reactions (SCARs). However, the strength of association was variable according to phenotypes and ethnic backgrounds. To explore genetic markers for allopurinol-induced SCARs in Koreans, we genotyped human leukocyte antigen (HLA) class I alleles of 25 cases of allopurinol-induced SCARs (20 cases of drug-induced hypersensitivity syndrome and five cases of Stevens-Johnson syndrome/toxic epidermal necrolysis) and 57 patients tolerant to allopurinol. Frequencies of B*5801 [92.0 vs. 10.5%, Pc=2. 45×10-11, odds ratio (OR)=97.8], Cw*0302 (92.0 vs. 12.3%, Pc=9.39×10-11, OR=82.1), and A*3303 (88.0 vs. 26.3%, Pc=3.31×10-11, OR=20.5) were significantly higher in SCARs compared with tolerant controls. In contrast, A*0201 was not found in SCARs patients despite relatively high frequency in tolerant controls (29.8%). We found strong positive association of HLA-B*5801 and negative association of HLA-A*0201 with the development of allopurinol-induced SCARs in the Korean population. © 2011 Wolters Kluwer Health | Lippincott Williams and Wilkins.

Cite

CITATION STYLE

APA

Kang, H. R., Jee, Y. K., Kim, Y. S., Lee, C. H., Jung, J. W., Kim, S. H., … Lee, K. W. (2011). Positive and negative associations of HLA class i alleles with allopurinol-induced SCARs in Koreans. Pharmacogenetics and Genomics, 21(5), 303–307. https://doi.org/10.1097/FPC.0b013e32834282b8

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free