Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC 50's 14 and 15 μM. © 2011 Elsevier Inc. All rights reserved.
CITATION STYLE
Shin, K., Chin, J., Hahn, D., Lee, J., Hwang, H., Won, D. H., … Kang, H. (2012). Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists. Steroids, 77(5), 355–359. https://doi.org/10.1016/j.steroids.2011.12.027
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