Conformationally constrained amino acid derivatives are useful in the synthesis of peptidomimetics. Seven-, and eightmembered conformationally constrained α-imino acid derivatives have been prepared via RCM (ring-closing metathesis). Interestingly, attempts to achieve the synthesis of nine-membered imino acid derivative resulted in the formation of dimeric, 18membered macrocyclic bis-a-imino acid derivative.
CITATION STYLE
Kotha, S., & Khedkar, P. (2007). Synthesis of conformationally constrained elimino acid derivatives via ring-closing metathesis. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 46(6), 975–979. https://doi.org/10.1002/chin.200740161
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