Syntheses of PNA monomers whose nucleobases are protected with Boc group are described. To overcome the solubility problem of carboxymethyl-guanine derivative, we introduced 2-trimethylsilylethyl group at O6 as a second protecting group.
CITATION STYLE
Sugiyama, T., Kittaka, A., Takemoto, Y., Takayama, H., & Kuroda, R. (2002). Synthesis of PNA using a Fmoc/Boc protecting group strategy. Nucleic Acids Research. Supplement (2001), (2), 145–146. https://doi.org/10.1093/nass/2.1.145
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