Teorias biológicas do envelhecimento

Abstract

Aging rate is the result of genomic and stochastic factors interactions. If organic capacity to face the insults of stochastic factors is insuffi- cient, cell imbalance should income leading to increase susceptibility to accumulate damage, which is patent on cell, tissue and organic aging phenomenon. To understand this phenomenon it’s necessary to recogni- ze the specific biologic mechanisms that underlie these imbalances, and that lead to the progressive age-related deterioration in function, cau- sing an increase in susceptibility to disease, and thereby enhancing the risk of death. Related interest on this problem encourages the develop- ment of several biologic theories of aging, some of them supported on genetic factors, and the others focused on the stochastic mechanisms. Some of the most popular biological theories of aging will be reviewed in this paper.