To assess the importance of B cell control of T cell differentiation, we analyzed the course of the T helper type I (THI)-driven disease experimental autoimmune encephalomyelitis in mice with an altered B cell compartment. We found that recovery was dependent on the presence of autoantigen-reactive B cells. B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen. With a bone marrow chimeric system, we generated mice in which IL-10 deficiency was restricted to B cells but not T cells. In the absence of IL-10 production by B cells, the pro-inflammatory type I immune response persisted and mice did not recover. These data show that B cell-derived IL- 10 plays a key role in controlling autoimmunity.
CITATION STYLE
Fillatreau, S., Sweenie, C. H., McGeachy, M. J., Gray, D., & Anderton, S. M. (2002). B cells regulate autoimmunity by provision of IL-10. Nature Immunology, 3(10), 944–950. https://doi.org/10.1038/ni833
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