The possibility that impaired production of bronchoprotective factors contributes to the pathogenesis of asthma cannot be excluded. Prostaglandin E2 (PGE2) could be such a factor. It is a dominant cyclo-oxygenase product of airway epithelium and smooth muscle; it has inhibitory effects on inflammatory cells and pathways involved in bronchoconstriction at concentrations known to occur in the airway; inhalation of PGE2 has considerable bronchoprotective effects in patients with asthma; and manoeuvres that increase or decrease endogenous production of PGE2 have beneficial and deleterious effects on airway function. © 1995.
CITATION STYLE
Pavord, I. D., & Tattersfield, A. E. (1995). Bronchoprotective role for endogenous prostaglandin E2. The Lancet, 345(8947), 436–438. https://doi.org/10.1016/S0140-6736(95)90409-3
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