Dopaminergic and serotoninergic mechanisms in the action of clozapine.

Abstract

the intriguing possibility that the enhanced antipsychotic efficacy of clozapine is also based in part on its ability to modulate DA [dopamine] release will be discussed in detail / the importance of clozapine as a serotonin (5HT) antagonist and its ability to increase 5HT release will be emphasized and the importance of the relationship between 5HT[subscript]2 and D[subscript]2 antagonism considered recent multicenter trials have shown that clozapine may be a more effective antipsychotic agent than chlorpromazine in chronic schizophrenic patients with TD [tardive dyskinesia] (PsycINFO Database Record (c) 2012 APA, all rights reserved). (chapter)