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Engineering the chloroplast targeted malarial vaccine antigens in Chlamydomonas starch granules

by David Dauvillée, Stéphane Delhaye, Sébastien Gruyer, Christian Slomianny, Samuel E. Moretz, Christophe d'Hulst, Carole A. Long, Steven G. Ball, Stanislas Tomavo show all authors


Malaria, an Anopheles-borne parasitic disease, remains a major global health problem causing illness and death that disproportionately affects developing countries. Despite the incidence of malaria, which remains one of the most severe infections of human populations, there is no licensed vaccine against this life-threatening disease. In this context, we decided to explore the expression of Plasmodium vaccine antigens fused to the granule bound starch synthase (GBSS), the major protein associated to the starch matrix in all starch-accumulating plants and algae such as Chlamydomonas reinhardtii.

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