Skip to content

Evolution of primate ABO blood group genes and their homologous genes.

by N Saitou, F Yamamoto
Molecular biology and evolution ()
Get full text at journal


There are three common alleles (A, B, and O) at the human ABO blood group locus. We compared nucleotide sequences of these alleles, and relatively large numbers of nucleotide differences were found among them. These differences correspond to the divergence time of at least a few million years, which is unusually large for a human allelic divergence under neutral evolution. We constructed phylogenetic networks of human and nonhuman primate ABO alleles, and at least three independent appearances of B alleles from the ancestral A form were observed. These results suggest that some kind of balancing selection may have been operating at the ABO locus. We also constructed phylogenetic trees of ABO and their evolutionarily related alpha-1,3-galactosyltransferase genes, and the divergence time between these two families was estimated to be roughly 400 MYA.

Author-supplied keywords

Cite this document (BETA)

Readership Statistics

57 Readers on Mendeley
by Discipline
77% Agricultural and Biological Sciences
5% Medicine and Dentistry
4% Chemistry
by Academic Status
21% Researcher
18% Student > Bachelor
16% Student > Ph. D. Student
by Country
5% United States
4% Indonesia
4% Canada

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in